Tag

platelet rich plasma
Saline Used As Placebo

On Using Saline as a Placebo: When Is a Placebo Not a Placebo? Part Two

In the previous post, I reviewed evidence presented in Bar-Or, et al. concerning the potential analgesic activity of saline used as a placebo in clinical studies. The authors provided evidence that saline didn’t act as an “inert” material in clinical studies. I will cover the authors thoughts on possible mechanisms for the saline’s analgesic activity...
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Saline Injections as Placebo

On Using Saline as a Placebo: When Is a Placebo Not a Placebo? Part One

Recently, while preparing a presentation on the current status of PRP and its clinical utility, I was struck by the large number of studies that rely on physiological saline as a placebo in double blinded, placebo-controlled clinical studies. This type of study is considered to be the gold standard format for performing clinical studies, since...
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Method of Ratios and PLT

Comments from Physicians on the Arthrex Angel Lemon/Lemonade Posts Highlight the Utility of the Method of Ratios – Part Two

In the previous post, I had shared a couple of comments from physicians (Drs. Sairam Atluri and Dr. Edward Marcheschi) that had been made on the trio of posts on the Arthrex Angel in which I concluded that the Arthrex Angel system was a lemon as a PRP/BMC processing technology. In exploring aspects of the...
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Arthrex Angel and Method of Ratios

Comments from Physicians on the Arthrex Angel Lemon/Lemonade Posts Highlight the Utility of the Method of Ratios – Part One

The posts that I write are available on the Greyledge website and are also distributed on LinkedIn. I would like to share a couple of LinkedIn comments from physicians who responded to the last three posts that have covered this question: Is the Arthrex Angel PRP/BMC processing system a lemon or has Arthrex’s marketing group made...
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Arthrex Angel System

Is the Arthrex Angel System a Lemon or Have They Made Lemonade? Part Three

In the previous two posts (Part One and Part Two), I have reviewed aspects of the performance of the Arthrex Angel system, which is being marketed to orthopedic surgeons to produce PRP and BMC for therapeutic treatments. I have covered the basics of the system and reviewed data from a publication that compared the cellular...
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Is the Arthrex Angel System a Lemon or Have They Made Lemonade? Part Two

In the previous post, I referred to comments that surgeons had shared with me at the AOSSM conference in early July about the Arthrex Angel system, which Arthrex markets to produce hematocrit (Hct)-specific PRP and BMC preparations. None of the surgeons I asked was able to provide any evidence that specific Hct levels were of...
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Arthrex Angel System Hct

Is the Arthrex Angel System a Lemon or Have They Made Lemonade? Part One

Recently, I staffed Greyledge’s booth at the AOSSM meeting held in San Diego, CA in early July. And I have to say it was an interesting experience due to the number of enquires I fielded from physicians who wanted to know if the Greyledge manual processing method in a biological safety cabinet with hemoanalysis of...
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Misunderstand BMA and Fat Grafting

Misunderstanding BMA and a Regulatory Framework for Thinking About Combination Cell-Based Therapies – Part Three

In the previous two posts (Part One and Part Two), I have examined comments made by Gassman, et al. in which they erroneously stated that bone marrow aspiration is painful and that it is associated with increased aspiration site morbidity. Their comments were directed at an article by Xing, et al. published together in the...
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Lipoaspirate treatments

Combination Cell-Based Therapies: A Very Sparse Record Except for Combo-Fat Grafting with Bone Marrow – Part Three

In the past couple of posts (Part One and Part Two of this series), I have reviewed a study by Xing, et al. in which the authors combined minced fat tissue with BMA, BMC or PBS (phosphate buffered saline) to assess the impact of each material for promoting viability of fat grafts in a rabbit...
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Bone Marrow-Derived Cells

Combination Cell-Based Therapies: A Very Sparse Record Except for Combo-Fat Grafting with Bone Marrow – Part Two

In the last post, I had finished covering the experimental design and describing the fluids Xing, et al. used in a study of the influence of bone marrow-derived fluid to augment fat graft survival in the rabbit. I will continue in this post with a review of the results they reported. Refer to Part One...
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