How Greyledge Works

Medical Biologics and Cellular Therapies

How Greyledge Works

Greyledge innovates the field of Regenerative Medicine with the goal of providing physicians with the technology and quality system to treat patients with a variety of autologous (meaning “from the patient’s own body) biologic preparations as part of their own practices. The advantage of Greyledge’s technology is its systemized approach, which supports a physician in effectively offering autologous biological preparations customized to their patients’ needs.

The use of a patient’s own plasma complements their body’s natural healing process, but an optimized biologic preparation is dependent on an additional variety of components. These components are as follows:

• Cells: Multiple types of cells participate in the natural healing process, and all are necessary in the preparation of autologous cellular therapies. These essential cells include Mesenchymal Stem Cells (MSCs) and Hematopoietic Stem Cells (HSCs), and other Multipotent Cells, originating from bone marrow and blood. Many cell types work with native tissue cells, to stimulate healing, inflammation control and proliferation in response to growth factor signals.
• Signals: This refers to a variety of human growth factors and other proteins, which primarily are present in plasma and platelets, but also can be produced by progenitor cells like MSCs.
• Scaffolds: This refers to a matrix made of proteins that supports tissue growth within the body. In the process described here, the primary protein typically is blood-based fibrinogen, which upon activation by the clotting cascade can create a multi-protein component scaffold that allows damaged tissue to rebuild.

Any element of this trio of active components present in a patient’s autologous biologic preparations — or a combination of the three — can be applied by a trained physician or cosmetic specialist to injured, pathologic, or undesirable tissue to support repair, either by injection or surgical application.