Tag

clinical study
Saline Used As Placebo

On Using Saline as a Placebo: When Is a Placebo Not a Placebo? Part Two

In the previous post, I reviewed evidence presented in Bar-Or, et al. concerning the potential analgesic activity of saline used as a placebo in clinical studies. The authors provided evidence that saline didn’t act as an “inert” material in clinical studies. I will cover the authors thoughts on possible mechanisms for the saline’s analgesic activity...
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Saline Injections as Placebo

On Using Saline as a Placebo: When Is a Placebo Not a Placebo? Part One

Recently, while preparing a presentation on the current status of PRP and its clinical utility, I was struck by the large number of studies that rely on physiological saline as a placebo in double blinded, placebo-controlled clinical studies. This type of study is considered to be the gold standard format for performing clinical studies, since...
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Degenerative Disc Disease Treated with BMC

BMC as Degenerative Disc Disease Treatment – Part Four

The focus of the previous three posts (Part One, Part Two, and Part Three) has been on reviewing various aspects of a paper recently published on the three-year milestone data of a clinical study in which study subjects had their own BMC injected into a 1-level or 2-level degenerative disc pathology in an attempt to...
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Degenerative Disc Disease BMC Treatment

Three Year Follow Up on Using BMC to Treat Degenerative Disc Disease – Part Three

The topic of the last two posts (Part One and Part Two) has been the recent publication of three-year milestone data of a clinical study investigating the safety and feasibility of treating lumbar degenerative disc disease with an autologous injection of bone marrow concentrate (BMC).  The three-year milestone publication naturally follows the previous publication of...
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Degenerative Disc Disease BMC Treatment

Three Year Follow Up on Using BMC to Treat Degenerative Disc Disease – Part Two

I started reviewing in the last post details from the publication of the three-year milestone outcomes for a clinical study on treating degenerative disc disease with BMC. See the previous post for the link to the article in PubMed and my statement concerning the fact that I am a co-author on the paper, along with...
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BMC to Treat Disc Disease

Three Year Follow Up on Using BMC to Treat Degenerative Disc Disease – Part One

Sometimes it is good to get away on vacation, which is why I didn’t have a new post for the Blog last week. Not only did I get a break from the routine, but the god for post topics smiled on me and a paper entitled “Autologous bone marrow concentrate intradiscal injection for the treatment...
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Fractured Long Bone Non-Unions

Hernigou’s BMC Treatment of Fractured Long-bone Non-unions

In the last post, I focused solely on adverse events associated with the bone marrow aspiration (BMA) procedure itself. In this post, I would like to return to another of Dr. Hernigou’s classic publications on the use of BMC to treat long-bone non-unions. I covered his publication on the benefits of BMC-augmentation of a surgical...
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Intact Tendon

Fixing Rotator Cuff Tears with Bone Marrow Concentrate—Beating the Odds for an Intact Tendon at 10-Years – Part Two

In the previous post, I started reviewing a classic paper published by Dr. Philippe Hernigou and co-workers, entitled “Biological augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study.” I will continue in this post by reporting on clinical outcomes from the study. Most importantly,...
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Rotator Cuff

Fixing Rotator Cuff Tears with Bone Marrow Concentrate—Beating the Odds for an Intact Tendon at 10-Years – Part One

Dr. Philippe Hernigou published a paper in 2014 entitled “Biological augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study.” I selected this paper to start my review of Dr. Hernigou’s extensive clinical study series on BMC therapy for orthopedic pathologies in part because it has...
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Hernigou Treatment

Filling the FDA’s Gaps on BMC and Clinical Studies with the help of Dr. Hernigou

The past couple of posts (No Increased Cancer Risk from Your Autologous BMC Treatment and Making Sense of Your Environment—if You are a Stem Cell) have covered aspects of the puzzling and misleading article FDA personnel published in the New England Journal of Medicine (NEJM) last November. In particular, the authors complained about the lack...
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