cell therapy
Degenerative Disc Disease BMC Treatment

Three Year Follow Up on Using BMC to Treat Degenerative Disc Disease – Part Three

The topic of the last two posts (Part One and Part Two) has been the recent publication of three-year milestone data of a clinical study investigating the safety and feasibility of treating lumbar degenerative disc disease with an autologous injection of bone marrow concentrate (BMC).  The three-year milestone publication naturally follows the previous publication of...
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Degenerative Disc Disease BMC Treatment

Three Year Follow Up on Using BMC to Treat Degenerative Disc Disease – Part Two

I started reviewing in the last post details from the publication of the three-year milestone outcomes for a clinical study on treating degenerative disc disease with BMC. See the previous post for the link to the article in PubMed and my statement concerning the fact that I am a co-author on the paper, along with...
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BMC to Treat Disc Disease

Three Year Follow Up on Using BMC to Treat Degenerative Disc Disease – Part One

Sometimes it is good to get away on vacation, which is why I didn’t have a new post for the Blog last week. Not only did I get a break from the routine, but the god for post topics smiled on me and a paper entitled “Autologous bone marrow concentrate intradiscal injection for the treatment...
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Amniotic Fluid-derived Information

The Astonishing Mis-information Being Shared on Amniotic Fluid-Derived Products – Part Two

I would like to finish up with my review of outrageous mis-information being spread about by some advocates of amniotic fluid-derived products. My focus has been on a Powerpoint presentation (PPt) made available to the public by Dr. Davidson. So far, I have pointed out what I contend are discrepancies in some of his statements,...
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Fact Check Amniotic Fluid

The Astonishing Mis-information Being Shared on Amniotic Fluid Products – Part One

Although I recently covered amniotic products in a couple of posts (Another Amniotic-derived Product Mis-states FDA Compliance and Addressing the Flood of Placental Tissue-based HCT/P Products, Again), and thought I could escape the morass that is amniotic fluid containing products, I came across a Powerpoint presentation (PPt) offered up by Dr. Davidson (Park City, Utah) Nanofactor...
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Placental Tissue-based HCT/P Products

Addressing the Flood of Placental Tissue-based HCT/P Products, Again

 In the previous post, I began a review of a marketing blurb sent to my boss, Dr. David Karli, extolling the virtues of an amniotic fluid-containing product. I am sure you are wondering why I haven’t mentioned the name of the manufacturer and the offending product, but see the explanation provided in the previous post....
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Amniotic-derived Product False Claim

Another Amniotic-derived Product Mis-states FDA Compliance

During a course offered by ASIPP last March in Las Vegas, NV, I gave a brief impromptu presentation about regulatory issues in the field of translational regenerative medicine. I mentioned that producers of placental tissue-derived products, like amniotic fluid products or amniotic fluid plus micronized amniotic tissue products, were sprouting like weeds, despite the issuing...
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Fractured Long Bone Non-Unions

Hernigou’s BMC Treatment of Fractured Long-bone Non-unions

In the last post, I focused solely on adverse events associated with the bone marrow aspiration (BMA) procedure itself. In this post, I would like to return to another of Dr. Hernigou’s classic publications on the use of BMC to treat long-bone non-unions. I covered his publication on the benefits of BMC-augmentation of a surgical...
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Intact Tendon

Fixing Rotator Cuff Tears with Bone Marrow Concentrate—Beating the Odds for an Intact Tendon at 10-Years – Part Two

In the previous post, I started reviewing a classic paper published by Dr. Philippe Hernigou and co-workers, entitled “Biological augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study.” I will continue in this post by reporting on clinical outcomes from the study. Most importantly,...
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Stem Cell

Making Sense of Your Environment—if You are a Stem Cell

In a previous post, I commented on a paper recently published in the New England Journal of Medicine (NEJM) in which FDA personnel expressed their dissatisfaction with the lack of solid, Level 1 clinical trials for the use of stem cell therapies by citing the lack of systematic recording of adverse events and a lack...
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